Process for preparing amino crotonyl compounds

US8426586B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Rainer Soyka · Biberach, DE
• Werner Rall · Mittelbiberach, DE
• Juergen Schnaubelt · Biberach, DE
• Peter Sieger · Mittelbiberach, DE
• Christian Kulinna · Mainz, DE

Key dates

• Filing date: Jul 14, 2006
• Grant date: Apr 23, 2013
• Expiry date: Aug 8, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.