Method for preparing montelukast sodium salts
US8426600B2 · kind B2 · utility
1Cited by
3References
15Claims
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Key dates
| Filing date | Sep 25, 2009 |
| Grant date | Apr 23, 2013 |
| Priority date | — |
| Expiry date | Jan 26, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a method for preparing a montelukast sodium salt of Formula 1. The method includes coupling a methanesulfonyl compound of Formula 2 below with a compound of Formula 3 below in the presence of a bistrimethylsilylamide alkali metal salt, further adding an alkali metal base thereto and hydrolyzing the mixture by heating to prepare a compound of Formula 4 below, reacting the compound of Formula 4 with 4-tert-butylcyclohexylamine, followed by purification, to prepare an amine salt of Formula 5, and converting the amine salt of Formula 5 into a sodium salt.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.