Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair

US8431397B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Richard B. Robinson · Cresskill, US
• Michael R. Rosen · New York, US
• Ira S. Cohen · Stony Brook, US
• Peter R. Brink · Setauket, US
• Glenn Gaudette · Holden, US
• Irina Potapova · Stony Brook, US

Key dates

• Filing date: Sep 14, 2005
• Grant date: Apr 30, 2013
• Expiry date: Mar 14, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N5/0657
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method for treating a subject afflicted with a cardiac disorder, in vivo, comprises (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell; and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject. This invention further provides related articles of manufacture and methods.