2,4-diaminopyrimidine derivatives

US8431589B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Rolf Baenteli · Basel, CH
• Gerhard Zenke · Rheinfelden (Baden), DE
• Nigel Graham Cooke · Oberwil, CH
• Rudolf Duthaler · Bettingen, CH
• Gebhard Thoma · Lörrach, DE
• Anette Von Matt · Basel, CH
• Toshiyuki Honda · Tsukuba, JP
• Naoko Matsuura · Tsukuba, JP
• Kazuhiko Nonomura · Tsukuba, JP
• Osamu Ohmori · Tsukuba, JP
• Ichiro Umemura · Tsukuba, JP
• Klaus Hinterding · Kohren-Sahlis, DE
• Christos Papageorgiou · Riedisheim, FR

Key dates

• Filing date: Mar 23, 2011
• Grant date: Apr 30, 2013
• Expiry date: Mar 23, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are provided compounds of formula Iwherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1 , useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.