Process for the preparation of water-in-oil and oil-in-water nanoemulsions
US8431620B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 28, 2007 |
| Grant date | Apr 30, 2013 |
| Priority date | — |
| Expiry date | Apr 28, 2030 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01F23/4142
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Process for the preparation of a water-in-oil or oil-in-water nanoemulsion wherein the dispersed phase is distributed in the dispersing phase in the form of droplets having a diameter ranging from 1 to 500 nm, comprising: 1) the preparation of a homogeneous water/oil blend (I) characterized by an interface tension lower than 1 mN/m, comprising water in an amount of 30 to 70% by weight, at least two surface-active agents having a different HLB, selected from non-ionic, anionic, polymeric surface-active agents, said surface-active agents being present in such a quantity as to make the blend homogeneous; 2) the dilution of the blend (I) in a dispersing phase consisting of oil or water with the addition of a surface-active agent, selected from non-ionic, anionic, polymeric surface-active agents, the quantity of the dispersing phase and surface-active agent being such as to obtain a nanoemulsion having a HLB different from that of the blend (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.