Transgenic non-human animal and methods for stem cell engraftment
US8431767B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Nov 9, 2010 |
| Grant date | Apr 30, 2013 |
| Priority date | — |
| Expiry date | Apr 1, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0387
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Transgenic immunodeficient non-human animals according to embodiments of the present invention are described which include in their genome a nucleic acid encoding xenogeneic Stem Cell Factor operably linked to a promoter. Administration of xenogeneic hematopoetic stem cells to the inventive transgenic animals results in engraftment of the xenogeneic hematopoetic stem cells and xenogeneic leukocytes are produced in the animals, without conditioning such as without conditioning by irradiation and without conditioning by a radiomimetic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.