Fusion proteins of HIV regulatory/accessory proteins

US8435535B2 · kind B2 · utility

Assignee

• Bavarian Nordic A/S · DK

Inventors

• Paul Howley · Scone, AU
• Sonja Leyrer · Munich, DE
• Eva Felder · Munich, DE

Key dates

• Filing date: Feb 14, 2012
• Grant date: May 7, 2013
• Expiry date: Feb 14, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16334
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.