Chimeric ligand-gated ion channels and methods of use thereof
US8435762B2 · kind B2 · utility
13Cited by
5References
60Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 9, 2009 |
| Grant date | May 7, 2013 |
| Priority date | — |
| Expiry date | Jan 14, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel chimeric receptors that have unique pharmacology. In particular, the chimeric receptors comprise a mutated ligand binding domain of the α7 nicotinic acetylcholine receptor fused to a transmembrane or channel domain from a ligand-gated ion channel protein. The mutations in the ligand binding domain confer selective binding of compounds. Methods of using the novel chimeric receptors of the invention as well as compounds that preferentially bind and activate the chimeric receptors are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.