Alginate polyelectrolyte encapsulation of embryonic stem cells

US8435787B2 · kind B2 · utility

Assignee

• Rutgers, the State University of New Jersey · US

Inventors

• Tim Maguire · Piscataway, US
• Rene S. Schloss · Piscataway, US
• Martin L. Yarmush · Newton, US

Key dates

• Filing date: May 9, 2006
• Grant date: May 7, 2013
• Expiry date: Dec 25, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Alginate polyelectrolyte encapsulation is used for the controlled differentiation of embryonic stem cells. An isolated cell population is provided. The cell population includes a single cell suspension of ES cells encapsulated within an alginate polyelectrolyte microenvironment. The encapsulated ES cells are capable of differentiating within said microenvironment into hepatocyte lineage cells in the absence of embryoid body intermediates or growth factor supplementation.