Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors

US8435977B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Chris Flores · Spring House, US
• Marina Nelen · Spring House, US
• Erica Nulton · Spring House, US
• Stephen Prouty · Philadelphia, US
• Matthew Todd · Spring House, US
• Sui-Po Zhang · Yeadon, US

Key dates

• Filing date: Apr 22, 2010
• Grant date: May 7, 2013
• Expiry date: Sep 26, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the inhibition of MGL, including pain. Such compounds are represented by Formula (I) as follows: are defined herein.