Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors

US8435985B2 · kind B2 · utility

Inventors

• Keith Allan Menear · Cambridge, GB
• Graeme Cameron Murray Smith · Cambridge, GB
• Karine Fabienne Malagu · Cambridge, GB
• Heather Mary Ellen Duggan · Macclesfield, GB
• Niall Morrison Barr Martin · Cambridge, GB
• Frederic Georges Marie Leroux · Horsham, GB

Key dates

• Filing date: Nov 30, 2011
• Grant date: May 7, 2013
• Expiry date: Nov 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D475/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided a compound of formula I:or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.