Uses of pentamidine and related compounds

US8436049B2 · kind B2 · utility

Assignee

• The State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon · US

Inventors

• John Andrew Berglund · Gainesville, US
• M. Bryan Warf · Eugene, US
• Catherine Matthys · Eugene, US
• Michael M. Haley · Eugene, US
• Cameron Hilton · Pleasant Grove, US

Key dates

• Filing date: Feb 20, 2009
• Grant date: May 7, 2013
• Expiry date: Jan 20, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods are provided herein for treatment of myotonic dystrophy and other toxic RNA diseases in a subject. In some examples, the method comprises administration of a compound that binds a nucleotide repeat expansion in a ribonucleic acid molecule, thereby treating the disease. In additional examples, the method comprises administration of a compound that disrupts binding of muscleblind-like proteins to an RNA nucleotide repeat expansion. Compounds for use in the disclosed method include pentamidine or heptamidine or derivatives thereof. Representative compounds are described herein.