Crystalline anti-hTNFalpha antibodies

US8436149B2 · kind B2 · utility

Assignee

• AbbVie Biotechnology Ltd. · BM

Inventors

• David W. Borhani · Worcester, US
• Wolfgang Fraunhofer · Gurnee, US
• Hans-Juergen Krause · Havelsee, DE
• Anette Koenigsdorfer · Ilvesheim, DE
• Gerhard Winter · Dossenheim, DE
• Stefan Gottschalk · Grünwald, DE

Key dates

• Filing date: Sep 2, 2011
• Grant date: May 7, 2013
• Expiry date: Sep 2, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a batch crystallization method for crystallizing an anti-hTNFalpha antibody which allows the production of said antibody on an industrial scale; antibody crystals as obtained according to said method; compositions containing said crystals as well as methods of use of said crystals and compositions.