Patent · US Active

Bispecific binding agents for modulating biological activity

US8440192B2 · kind B2 · utility

11Cited by

3References

21Claims

0Family size

Assignee

Merrimack Pharmaceuticals, Inc. · US

Inventors

Ulrik Nielsen · Quincy, US
Birgit Schoeberl · Cambridge, US

Key dates

Filing date	Jan 18, 2012
Grant date	May 14, 2013
Priority date	—
Expiry date	Feb 14, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/92
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Methods for improving the biological and pharmaceutical properties of bispecific binding agents are described herein where the bispecific binding agents are able to target cells by a high affinity binding domain to a first cell surface marker that does not induce a significant biological effect and a low affinity binding domain that binds specifically to a second cell surface marker, causing a significant and desired biological effect. Compositions of such bispecific binding agents, uses for them, and kits containing them are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.