Sustained release pharmaceutical compositions comprising quetiapine in non-gellable polymers

US8440223B2 · kind B2 · utility

Assignee

• LUPIN LIMITED · IN

Inventors

• Avinash Krishnaji Velhal · Pune, IN
• Sunil Anantrao Mirajkar · Pune, IN
• Virendra Ramkrupal Kuril · Pune, IN
• Vineeth Raghavan · Pune, IN
• Ninad Deshpanday · Salt Lake City, US

Key dates

• Filing date: Jun 29, 2009
• Grant date: May 14, 2013
• Expiry date: Oct 13, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A sustained release dosage form comprising Quetiapine or a pharmaceutically acceptable salt, polymorphs, solvates, hydrates thereof and one or more non-gellable release controlling polymer and one or more pharmaceutically acceptable excipient(s). A sustained release dosage form comprising first granulation comprising Quetiapine or its pharmaceutically acceptable salts, polymorphs, solvates, hydrates thereof and one or more release controlling material; and second granulation comprising one or more release controlling material which is the same or different than the one or more release controlling material of the first granulation and optionally quetiapine or its pharmaceutically acceptable salts, polymorphs, solvates, hydrates thereof. A method of preparing the sustained release dosage form by first and second granulation followed by milling; blending the said milled granules after second granulation with lubricant followed by compression to form a sustained release dosage form. A sustained release dosage form comprising immediate release core comprising Quetiapine or a pharmaceutically acceptable salt, polymorphs, solvates, hydrates thereof and one or more pharmaceutically accepta…