Inhibitors of beta-lactamase
US8440643B2 · kind B2 · utility
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21Claims
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Assignee
Inventors
Key dates
| Filing date | May 21, 2007 |
| Grant date | May 14, 2013 |
| Priority date | — |
| Expiry date | Jan 24, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6561
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammomium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.