Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1

US8440658B2 · kind B2 · utility

Assignee

• Vitae Pharmaceuticals, LLC · US

Inventors

• David A. Claremon · Audubon, US
• Linghang Zhuang · Doylestown, US
• Colin M. Tice · Ambler, US
• Yuanjie Ye · Ambler, US
• Wei He · Audubon, US
• Suresh B. Singh · Kendall Park, US
• Zhenrong Xu · Forest Park, US
• Salvacion Cacatian · Conshohocken, US
• Wei Zhao · North Potomac, US

Key dates

• Filing date: Dec 10, 2008
• Grant date: May 14, 2013
• Expiry date: Jul 3, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a compound represented by Formula (I):or a pharmaceutically acceptable salt, monohydrate, enantiomer or diastereomer thereof. Also disclosed are pharmaceutical compositions comprising the compound of Formula (I) or a pharmaceutically acceptable salt, monohydrate, enantiomer or diastereomer thereof and methods of inhibiting 11β-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt, monohydrate, enantiomer or diastereomer thereof. Values for the variables in Formula (I) are defined herein.