Substituted quinazoline and pyrido-pyrimidine derivatives

US8440662B2 · kind B2 · utility

Assignee

• ENDO PHARMACEUTICALS INC. · US

Inventors

• Roger Smith · Madison, US
• Scott K. Thompson · Phoenixville, US
• Subramanya Hosahalli · Bengaluru, IN
• Mallesham Bejugam · Rasra, IN
• Srinivas Nanduri · Hyderabad, IN
• Sunil Kumar Panigrahi · Dashapalla, IN
• Natarajan Mahalingam · Ariyalur, IN

Key dates

• Filing date: Oct 31, 2011
• Grant date: May 14, 2013
• Expiry date: Oct 31, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.