Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
US8440677B2 · kind B2 · utility
4Cited by
44References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 24, 2010 |
| Grant date | May 14, 2013 |
| Priority date | — |
| Expiry date | Feb 18, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides compounds, compositions and methods to treat certain inflammatory conditions and/or oncology by administering a compound that inhibits PI3K isoforms, particularly the delta isoform. It further provides specific stereoisomers of a compound useful for these methods. In particular, the compound is an optically active atropisomer of 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.