Bicyclic compounds and their uses as dual c-SRC / JAK inhibitors
US8440679B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 17, 2011 |
| Grant date | May 14, 2013 |
| Priority date | — |
| Expiry date | Feb 17, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to substituted aromatic bicyclic compounds containing pyrimidine and pyridine rings of formula (I) having the structure as well as pharmaceutically acceptable salts thereof. The compounds of the present invention are useful as tyrosine kinase inhibitors, preferably SRC family kinases (SFKs) inhibitors, in particular as multi SFK/JAK. kinases inhibitors and even preferably as dual c-SRC/JAK kinases inhibitors, thereby inhibiting the STAT3 activation and therefore abnormal growth of particular cell types. Notably, the compounds of the present invention are useful for the treatment or inhibition of certain diseases that are the result of deregulation of STAT3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.