Tetrahydroquinolinyl compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof

US8440691B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Arthur Gomtsyan · Vernon Hills, US
• Erol K. Bayburt · Gurnee, US
• Robert G. Schmidt · Waukegan, US
• Chih-Hung Lee · Vernon Hills, US
• Brian S. Brown · Evanston, US
• Tammie K. Jinkerson · Pleasant Prairie, US
• John R. Koenig · Chicago, US
• Jerome F. Daanen · Racine, US
• Steven P. Latshaw · Round Lake, US

Key dates

• Filing date: Sep 3, 2010
• Grant date: May 14, 2013
• Expiry date: Sep 3, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds that are antagonists of the VR1 receptor, having formula (I)or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.