Hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents
US8440692B2 · kind B2 · utility
2Cited by
4References
18Claims
0Family size
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Key dates
| Filing date | Dec 7, 2007 |
| Grant date | May 14, 2013 |
| Priority date | — |
| Expiry date | Dec 10, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/60
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.