Use of chloroquine to treat metabolic syndrome

US8440695B2 · kind B2 · utility

Assignees

• St. Jude Children's Research Hospital, Inc. · US
• Washington University · US

Inventors

• Michael Kastan · Cordova, US
• Clay F. Semenkovich · Ladue, US
• Jochen Schneider · Tettnang, DE

Key dates

• Filing date: Oct 31, 2006
• Grant date: May 14, 2013
• Expiry date: Oct 1, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions for modulating certain metabolic processes and for treating a variety of disorders associated with metabolic syndrome, including insulin related disorders, ischemia, oxidative stress, atherosclerosis, hypertension, obesity, abnormal lipid metabolism, and stroke by administering an effective dose of a chloroquine compound. The invention also provides methods and compositions relating to administering an effective dose of a chloroquine compound in combination with at least a second pharmaceutically active ingredient or compound including an antihyperglycemic diabetes treatment, an antihypertensive agent, an antithrombotic agent, and/or an inhibitor of cholesterol synthesis or absorption.