Methods of synthesis and/or purification of diaminophenothiazinium compounds
US8440821B2 · kind B2 · utility
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30Claims
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Key dates
| Filing date | May 31, 2011 |
| Grant date | May 14, 2013 |
| Priority date | — |
| Expiry date | May 31, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described is a method for the synthesis and/or purification of a high purity diaminophenothiazinium compound of the following formula:characterized by a purity of greater than 98% and less than 1% Azure B, 0.15% Azure A, 0.15% Azure C and 0.05% Methylene Violet Bernthsen (MVB), as impurities. Also described are related high purity compounds, compositions, and methods of using such compounds and compositions. The compounds and compositions are useful in the treatment of diseases caused by tau aggregation, such as Alzheimer's disease and other dementias, and infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.