Sulfonyl amide derivatives for the treatment of abnormal cell growth

US8440822B2 · kind B2 · utility

Inventors

• Michael Joseph Luzzio · Noank, US
• Kevin Daniel Freeman-Cook · Clinton, US
• Samit Kumar Bhattacharya · Groton, US
• Matthew Merrill Hayward · Old Lyme, US
• Catherine Angela Hulford · Preston, US
• Christopher Lowell Autry · New London, US
• Xumiao Zhao · East Lyme, US
• Jun Xiao · New London, US
• Kendra Louise Nelson · Mystic, US

Key dates

• Filing date: Jul 24, 2012
• Grant date: May 14, 2013
• Expiry date: Jul 24, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D475/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of the formula Iwherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.