Tetrahydro-fused pyridines as histone deacetylase inhibitors

US8440830B2 · kind B2 · utility

Assignee

• 4SC AG · DE

Inventors

• Thomas Maier · Stockach, DE
• Thomas Beckers · Konstanz, DE
• Thomas Baer · Edgerton, US
• Matthias Vennemann · Konstanz, DE
• Volker Gekeler · Konstanz, DE
• Astrid Zimmermann · Konstanz, DE
• Petra Gimmnich · Konstanz, DE
• Kamlesh Jyotindra Padiya · Ashti, IN
• Hemant Joshi · Navi Mumbai, IN
• Uday Mukund JOSHI · Thane, IN
• Mahindra Makhija · Mumbai, IN
• Dipak Harel · Jamkhed, IN

Key dates

• Filing date: Sep 19, 2008
• Grant date: May 14, 2013
• Expiry date: May 23, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases.