Antimicrobial compounds, their synthesis and their use for treatment of mammalian infections

US8440842B2 · kind B2 · utility

Assignee

• Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut · DE

Inventors

• Ute Moellmann · Jena, DE
• Vadim Makarov · Moscow, RU
• Cole Stewart · Châtillon, FR

Key dates

• Filing date: Jun 25, 2008
• Grant date: May 14, 2013
• Expiry date: May 7, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of Formula (I)or salts thereof wherein R1, R2, R3, R4, R5, R6, and other variables enumerated under one or more of same are as defined herein. Compounds of Formula I have activity as antimicrobial agents. Also disclosed are pharmaceutical compositions and methods of treating and preventing microbial infections in mammals, for example, a tuberculosis or leprosy infection, which employ compounds of Formula (I) or salts thereof.