Method of preparing an immunologically-active adjuvant-bound dried vaccine composition

US8444991B2 · kind B2 · utility

Assignee

• The Regents of the University of Colorado, a Body Corporate · US

Inventors

• Theodore W. Randolph · Niwot, US
• Amber Clausi · Easton, US
• John Carpenter · Littleton, US
• Daniel K. Schwartz · Boulder, US

Key dates

• Filing date: Mar 18, 2008
• Grant date: May 21, 2013
• Expiry date: Feb 14, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides a method of preparing an immunologically-active adjuvant-bound freeze dried vaccine composition. A specific embodiment provides a stable vaccine composition comprising an aluminum-salt adjuvant, a recombinant Clostridium botulinum neurotoxin protein and a glass-forming agent. These vaccine compositions are useful in the treatment of humans and other animals at risk of infection from Clostridium botulinum neurotoxin.