Patent · US Active

Preparation of micro-porous crystals and conjugates thereof

US8445214B2 · kind B2 · utility

0Cited by

1References

6Claims

0Family size

Assignee

Roche Diagnostics Operations, Inc. · US

Inventors

Zoran D. Popovic · Täby, SE
Manuel Matthias Tsotsalas · Mülheim an der Ruhr, DE
Michael Busby · Hachenburg, DE
Luisa De Cola · Strasbourg, FR
Gion Calzaferri · Bern, CH
Hans-Peter Josel · Weilheim, DE

Key dates

Filing date	May 3, 2011
Grant date	May 21, 2013
Priority date	—
Expiry date	May 3, 2031

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/582
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.