Patent · US Active

Method for creating perfusable microvessel systems

US8445280B2 · kind B2 · utility

2Cited by

7References

33Claims

0Family size

Assignee

NORTIS, INC. · US

Inventors

Thomas Neumann · Munich, DE
Anna V. Tourovskaia · Mountlake Terrace, US
Mark E. Fauver · Seattle, US
Julia Yu · Kirkland, US

Key dates

Filing date	Sep 24, 2008
Grant date	May 21, 2013
Priority date	—
Expiry date	Jul 3, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2533/50
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A method for creating networks of perfusable microvessels in vitro. Cells including cell types capable of sprouting are seeded 1300 into a channel in a matrix at to activate competency 1304 of the cells for sprouting as microvessels based on the seeding density. The matrix channel is perfused with medium to allow parent vessels to form and for viability 1324. The parent vessels and matrix are incubated and perfused to provide for sprouting of microvessels from parent vessels into the surrounding matrix 1328. The sprouting parent vessels are grown until network forms 1332.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.