Azetidinyl diamides as monoacylglycerol lipase inhibitors

US8445477B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Haiyan Bian · Princeton, US
• Kristen Chevalier · Collegeville, US
• Jose Clemente · West Chester, US
• Pete Connolly · Spring House, US
• Chris Flores · Spring House, US
• Shu-Chen Lin · Doylestown, US
• Li Liu · Doylestown, US
• John Mabus · East Greenville, US
• Mark J. Macielag · Spring House, US
• Mark McDonnell · Lansdale, US
• Philip Pitis · Valley Forge, US
• Yue-Mei Zhang · Wellesley, US
• Sui-Po Zhang · Yeadon, US
• Bin Zhu · Spring House, US

Key dates

• Filing date: Apr 22, 2010
• Grant date: May 21, 2013
• Expiry date: Oct 31, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:wherein Y, Z, R1, and s are defined herein.