Aryl ether pyridazinone derivatives

US8445489B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Frank Stieber · Heidelberg, DE
• Oliver Schadt · Rodenbach, DE
• Dieter Dorsch · Ober-Ramstadt, DE
• Andree Blaukat · Heilbad Heiligenstadt, DE

Key dates

• Filing date: May 2, 2008
• Grant date: May 21, 2013
• Expiry date: Jan 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I, in which R1, R2, R3, R4, R5 and X have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.