Patent · US Active

Conjugation reactions

US8445612B2 · kind B2 · utility

0Cited by

11References

4Claims

0Family size

Assignee

Biocompatibles UK Limited · GB

Inventors

Andrew Lennard Lewis · Leatherhead, GB
Simon Leppard · Leatherhead, GB

Key dates

Filing date	Sep 23, 2011
Grant date	May 21, 2013
Priority date	—
Expiry date	Sep 23, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08F4/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

An initiator for the terminal group of the polymer product of an atom or group radical transfer polymerisation has an activated carboxyl or an amine group which is reacted with an amine or carboxyl (respectively) group containing biologically active compound. The initiator is preferably 4-(3-(2-bromo, 2-methyl-propionate)phenyl)-propionic acid N-hydroxysuccinimide ester or 2-bromo, 2-methyl-propionic acid N-hydroxysuccinimide ester. The monomers preferably comprise a zwitterionic monomer such as 2-methacryloxyethyl-2′-trimethyl ammoniumethyl phosphate inner salt.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.