Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells
US8445638B2 · kind B2 · utility
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5References
20Claims
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Key dates
| Filing date | Sep 2, 2009 |
| Grant date | May 21, 2013 |
| Priority date | — |
| Expiry date | Sep 15, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.The present invention also relates to a truncated form of eIF-5A1 that is useful for inducing apoptosis and killing of cells, especially cancer cells in a mammal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.