Unnatural amino acids capable of covalently modifying protein phosphatases and their use as general and specific inhibitors and probes
US8445706B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 1, 2009 |
| Grant date | May 21, 2013 |
| Priority date | — |
| Expiry date | Apr 3, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6561
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An unnatural amino acid including a phosphate mimicking group for mimicking a phosphate group in phosphoamino acids and a protein phosphatase modifying group for covalently binding protein phosphatases. A probe for detecting disease including a phosphate mimicking group for mimicking a phosphate group in phosphoamino acids and a protein phosphatase modifying group for covalently binding protein phosphatases. A method for detecting the presence of disease by administering the unnatural amino acid, binding the unnatural amino acid with a phosphatase, detecting a signal, and detecting the presence of disease. A method of identifying a known protein phosphatase, and a method of identifying an unknown protein phosphatase. A method of making the unnatural amino acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.