Small volume in vitro analyte sensor and methods of making

US8449758B2 · kind B2 · utility

Assignee

• ABBOTT DIABETES CARE INC. · US

Inventors

• Benjamin J. Feldman · Oakland, US
• Adam Heller · Austin, US
• Ephraim Heller · Piedmont, US
• Fei Mao · Fremont, US
• Joseph A. Vivolo · San Francisco, US
• Jeffery V. Funderburk · Fremont, US
• Fredric C. Colman · Berkeley, US
• Rajesh Krishnan · San Leandro, US

Key dates

• Filing date: Sep 29, 2009
• Grant date: May 28, 2013
• Expiry date: Jun 11, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T156/1052
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.