Composition exhibiting enhanced formulation stability and delivery of topical active ingredients

US8449918B2 · kind B2 · utility

Assignee

• Sol-Gel Technologies Ltd. · IL

Inventors

• Noa Lapidot · Mevaseret Tsiyon, IL
• Shlomo Magdassi · Jerusalem, IL
• David Avnir · Jerusalem, IL
• Claudi Rottman · Jerusalem, IL
• Orit Gans · Rehovot, IL
• Alon Seri-Levy · Jerusalem, IL

Key dates

• Filing date: Sep 23, 2011
• Grant date: May 28, 2013
• Expiry date: Sep 23, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61Q17/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.