CGRP antagonists

US8450327B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Dirk Gottschling · Mittelbiberach, DE
• Georg Dahmann · Biberach an der Riß, DE
• Henri Doods · Warthausen, DE
• Annekatrin Heimann · Biberach, DE
• Stephan Georg Mueller · Warthausen, DE
• Klaus Rudolf · Warthausen, DE
• Gerhard Schaenzle · Biberach, DE
• Dirk Stenkamp · Biberach, DE

Key dates

• Filing date: Oct 16, 2008
• Grant date: May 28, 2013
• Expiry date: Jan 11, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel CGRP antagonists of the general formula (I) in which U, V, X, Y, R1, R2, R3 are defined as described below, the tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof, and the hydrates of the salts, particularly the physiologically compatible salts thereof having inorganic or organic acids or bases, pharmaceuticals comprising said compounds, the use thereof, and the method for the production thereof.