Gamma secretase modulators

US8450343B2 · kind B2 · utility

Inventors

• Xianhai Huang · Hackettstown, US
• Anandan Palani · Bound Brook, US
• Jun Qin · Edison, US
• Robert G. Aslanian · Rockaway, US
• Zhaoning Zhu · Plainsboro, US
• William J. Greenlee · Teaneck, US
• Hubert Josien · Hoboken, US
• Wei Zhou · Scotch Plains, US
• Xiaohong Zhu · Edison, US
• Chad E. Bennett · Metuchen, US
• Dmitri Pissarnitski · Scotch Plains, US
• Mihirbaran Mandal · Scotch Plains, US
• Pawan Dhondi · Elizabeth, US
• Troy McCracken · Berkeley Heights, US
• Thomas Bara · Linden, US
• Zhiqiang Zhao · Scotch Plains, US
• Duane A. Burnett · Wayland, US
• John W. Clader · Cranford, US

Key dates

• Filing date: Dec 4, 2008
• Grant date: May 28, 2013
• Expiry date: Feb 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).