Patent · US Active

Derivatives of squaric acid with anti-proliferative activity

US8450348B2 · kind B2 · utility

15Cited by

12References

13Claims

0Family size

Assignee

FORMA TM, LLC · US

Inventors

Krishna Murthi · Cambridge, US
Roland Köstler · Martinsried, DE
Chase C. Smith · Rutland, US
Tilman Brandstetter · Munich, DE
Arthur F. Kluge · Lincoln, US

Key dates

Filing date	Feb 21, 2007
Grant date	May 28, 2013
Priority date	—
Expiry date	Jun 13, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2501/06
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof. These compounds show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.