Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors

US8450354B2 · kind B2 · utility

Assignee

• High Point Pharmaceuticals, LLC · US

Inventors

• Adnan M. M. Mjalli · Oak Ridge, US
• Anitha Hari · High Point, US
• Bapu Gaddam · Ellicott City, US
• Devi Reddy Gohimukkula · Jamestown, US
• Dharma Rao Polisetti · High Point, US
• Mohan Rao · Greensboro, US
• Raju Bore Gowda · Oak Ridge, US
• Robert Carl Andrews · Jamestown, US
• Rongyuan Xie · Greensboro, US
• Soumya P. Sahoo · Old Bridge, US
• Tan Ren · High Point, US
• William Kenneth Banner · Greensboro, US

Key dates

• Filing date: Mar 21, 2011
• Grant date: May 28, 2013
• Expiry date: Mar 21, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutically acceptable salts thereof, and tautomers of any of the foregoing, where such compounds inhibit β-site amyloid precursor protein-cleaving enzyme (BACE), which may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention also provides pharmaceutical compositions comprising any of these compounds and the use of any of these compounds and compositions in the treatment of diseases, disorders, or conditions in which BACE is involved.