Compositions for inhibiting ABAD/ABeta protein interaction

US8450454B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Shi Du Yan · New York, US
• David M. Stern · Great Neck, US
• Joyce Lustbader · Tenafly, US
• Hao Wu · Shanghai, CN

Key dates

• Filing date: Jan 13, 2011
• Grant date: May 28, 2013
• Expiry date: Jan 13, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides methods, compositions and articles of manufacture for inhibiting binding between Aβ protein and ABAD in cells. Uses of this invention include, for example, treating Alzheimer's disease; reducing free radical generation, DNA fragmentation, and cytochrome C release in cells; and preserving cell viability by preventing LDH release from a cell.