Nucleic acid inhibitors of glutamate receptors

US8450468B2 · kind B2 · utility

Assignees

• The Research Foundation for The State University of New York · US
• Cornell University · IT

Inventors

• Li Niu · Loudonville, US
• Zhen Huang · Brooklyn, US
• Hua Shi · Ithaca, US
• John T. Lis · Ithaca, US

Key dates

• Filing date: Dec 12, 2011
• Grant date: May 28, 2013
• Expiry date: Dec 12, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/16
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.