6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors

US8450486B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Dominique Jean-Pierre Mabire · La Saussaye, FR
• Jérôme Emile Georges Guillemont · Andé, FR
• Jacobus Alphonsus Josephus Van Dun · Kasterlee, BE
• Maria Victorina Francisca Somers · Vosselaar, BE
• Walter Boudewijn Leopold Wouters · Kapellen, BE

Key dates

• Filing date: Oct 28, 2011
• Grant date: May 28, 2013
• Expiry date: Oct 28, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitorswherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.