Process for the preparation of cis-2-methylspiro (1,3-oxathiolane 5-3′) quinuclidine
US8450487B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Jun 8, 2010 |
| Grant date | May 28, 2013 |
| Priority date | — |
| Expiry date | Oct 18, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D453/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods are provided for making pharmaceutical-grade cis-2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine and pharmaceutically acceptable salts thereof by isomerizing racemic 2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine to cis-2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine and subsequent purification of the C-MSOQ by salt formation with inexpensive and commercially available material such as sulfuric acid. Purification methods are disclosed which employ an organic solvent/water system and recrystallization with an organic solvent such as acetone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.