Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria
US8455224B2 · kind B2 · utility
39Cited by
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16Claims
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Key dates
| Filing date | Sep 29, 2009 |
| Grant date | Jun 4, 2013 |
| Priority date | — |
| Expiry date | Sep 29, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02E50/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A high flux of metabolites from pyruvate to 2,3-butanediol in Lactobacillus plantarum was achieved through genetic engineering. Substantial elimination of lactate dehydrogenase activity in the presence of heterologously expressed butanediol dehydrogenase activity led to 2,3 butanediol production that was at least 49% of the total of major pyruvate-derived products.
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