Peptides having binding affinity to an antibody which recognizes an epitope on an α1 loop 2 or β2 loop 1 of an adrenoreceptor

US8455442B2 · kind B2 · utility

Assignees

• MDC Max-Delbruck-Centrum Fur Molekulare Medizin Berlin-Buch · DE
• Fresenius Medical Care Deutschland GmbH · DE

Inventors

• Rudolf Kunze · Berlin, DE
• Gerd Wallukat · Berlin, DE
• Peter Rosenthal · West Simsbury, US
• Richard Straube · Lüdenscheid, DE

Key dates

• Filing date: Jan 15, 2009
• Grant date: Jun 4, 2013
• Expiry date: Jan 15, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop 1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.