Substituted spiro-amide compounds

US8455475B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Stefan Schunk · Aachen, DE
• Melanie Reich · Aachen, DE
• Stefan Oberboersch · Aachen, DE
• Michael Engels · Turnhout, BE
• Tieno Germann · Aachen, DE
• Ruth Jostock · Stolberg, DE
• Christa Kneip · Aachen, DE

Key dates

• Filing date: Mar 24, 2010
• Grant date: Jun 4, 2013
• Expiry date: Nov 27, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted spiro-amide compounds corresponding to formula Iin which R5 through R8, D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor.