Patent · US Active

Rapamycin carbonic ester analogues, pharmaceutical compositions, preparations and uses thereof

US8455510B2 · kind B2 · utility

15Cited by

1References

8Claims

0Family size

Assignee

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Fajun Nan · Shanghai, CN
Jian Ding · Shanghai, CN
Jianping Zuo · Shanghai, CN
Linqian Yu · Shanghai, CN
Linghua Meng · Shanghai, CN
Yangming Zhang · Shanghai, CN
Na Yang · Beijing, CN
Min Gu · Tangxia, CN

Key dates

Filing date	Sep 17, 2009
Grant date	Jun 4, 2013
Priority date	—
Expiry date	Sep 17, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/18
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Rapalogs of formula I, pharmaceutically acceptable salts, pharmaceutical compositions, and preparation methods and uses thereof. The rapalogs have the structure of formula I and can be used as an anti-tumor medicament. Comparing with rapamycin, the rapalogs of the present invention exhibit enhanced water solubility, and improved pharmacological and pharmacokinetic properties by introducing a hydrophilic and polar group such as a hydroxyl.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.