6-aminoisoquinoline compounds

US8455513B2 · kind B2 · utility

Assignee

• Aerie Pharmaceuticals, Inc. · US

Inventors

• Mitchell A. deLong · Chapel Hill, US
• Susan M. Royalty · Cary, US
• Jill Marie Sturdivant · Chapel Hill, US
• Geoffrey Richard Heintzelman · Annandale, US

Key dates

• Filing date: Jan 10, 2007
• Grant date: Jun 4, 2013
• Expiry date: Mar 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.